Fibrin is an insoluble protein the body produces in response to bleeding or inflammation. Fibrin performs important functions in the body, including clotting and wound healing. During the blood clotting process, the protein precursor fibrinogen is converted into fibrin, which forms a layer of connective tissue inside the damaged blood vessel. To do this, the fibrin strands assemble into a net-like structure over the damaged vessel and harden, forming a "patch" or small clot to prevent further damage.
Despite its protective function, excessive fibrin can do more harm than good. A high level of circulating fibrin has the potential to accelerate scarring, increase clot formation and impede normal blood flow. This can lead to increased blood viscosity, swelling, edema, pain, chronic inflammation and more serious fibrotic conditions or cardiovascular events.
According to Scripps Research Institute, "It is generally assumed that the persistence of fibrin in the extra cellular matrix (connective tissue) promotes fibrosis, and that the extent of fibrosis is limited by proteases (protein-digesting enzymes) that remove the fibrin. Fibrotic disease occurs when normal control of this process is compromised and excess fibrous material accumulates in the tissues."
The proteases in Serracor-NK® support normal fibrin levels, blood viscosity, overall blood circulation and healthy inflammation responses.*
Serracor-NK for Circulatory & Inflammation Support
Serracor-NK contains SEBkinase® with enteric coated serrapeptase and nattokinase, as found in the original Neprinol® formula.** We are the original manufacturer of this formula, imitated by many others (to learn more about Serracor-NK vs. Neprinol, please click the "Compare" tab).
SEBkinase brings together two enteric coated, fibrinolytic proteases: Peptizyme-SP® (Serrapeptase) and NattoSEB® (our Nattokinase is Vitamin K-free, since it assists in blood coagulation). Serracor NK further supports the activity of SEBkinase-CV with a complete array of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a comprehensive systemic enzyme blend designed to support maximum circulatory health.*
Serracor-NK also promotes healthy levels of C-reactive protein (CRP), an inflammation marker and serious risk factor for inflammation and cardiovascular disease.* In addition, the entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System® (BPPS).
Enteric coated Serrapeptase and Nattokinase: Why is it important?
Most nattokinase and serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating of our Serracor-NK SEBkinase blend allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the circulatory system maintaining high activity levels.*
The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines. If your enzyme formula is not enteric coated, you may be wasting your money (to learn more about enteric coating used in AST Enzymes products, please click the"Compare" tab).
How do Fibrinolytic Units (FU's) relate to enteric coating?
Enzyme activity measured in fibrinolytic units does not mean anything if the enzymes are destroyed and/or denatured in the high acidic conditions of the stomach. Under these conditions, our laboratory tests have consistently shown that serrapeptase and nattokinase lose significant activity when exposed to low pH (such as those in the stomach). In contrast, our enteric coated nattokinase and serrapeptase (the original SEBkinase formula) perform at greater activity levels in the same low pH conditions.
Enzyme Stabilization with BPPS®
The Bioactive Protein Peptides System (BPPS) is a system of peptides used to stabilize and enhance the activity of enzymes.
The Bioactive Protein Peptides System was developed by Specialty Enzymes and Biotechnologies (SEB) specifically for enzyme stability. Stabilizers have been used since SEB began manufacturing enzymes in 1957. The BPPS system was a significant advancement developed by SEB in the early 1990's.
It is true it was not trademarked until 2008, but it was in use long before. The reality is: a pure enzyme is not stable. It requires the addition of stabilizers in order to provide a reasonable shelf life. Because we are the actual manufacturer of enzymes with more than 50 years of manufacturing experience, our research and development team constantly works to improve stability and tolerance to the environments in which the enzymes interact. Marketing companies, on the other hand, will generally have significantly less understanding of the physio-chemical and kinetic properties of enzymes.
For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Serracor-NK dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit).
NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day.
Complementing your Serracor-NK with additional serrapeptase can increase fibrinolytic activity, as well as increase positive effects on blood pressure and inflammation, and reduce mucus viscosity in the respiratory system.*
Serra RX80 contains 80,000 units of professional-strength serrapeptase per capsule.